negatives of tirzepatide pros and cons shows greater average weight loss than semaglutide. 15% vs 20–22% on paper. But weight loss numbers don't tell the whole Frontiers | Ineffectiveness of tirzepatide

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By slowing the rate at which food moves from the stomach into the small intestine, tirzepatide helps regulate postprandial glucose excursions and promotes satiety

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For patients with known atrial fibrillation or a history of arrhythmias, semaglutide or liraglutide may be preferable first-line options due to lower palpitation rates