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Strategies to mitigate muscle loss Muscle talks to your gut during exercise: Physical activity triggers muscle release of IL-6 and other signals that actually boost GLP-1 production in the intestines, creating a natural feedback loop that supports metabolism

Ramirez T, Strigun A, Verlohner A et al (2017) Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells

Moreover, 18.9% of patients in the GLP1-RAs group required a repeat colonoscopy due to poor bowel preparation, compared to 11.1% of the controls ( p -value 0.041) [28]

Ipamorelin is a selective secretagogue, meaning it has a much lower impact on hunger than other peptides like GHRP-6

Buzzetti, R., Maddaloni, E., Gaglia, J., Leslie, R