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Ejtahed, H
Multiple observational studies have found that individuals with low B12 are significantly more likely to report depressive symptoms, and intervention studies show that correcting the deficiency improves mood outcomes sometimes substantially
What they found: Favorable safety profile , no serious adverse events at doses up to 100 g/kg Preliminary efficacy signals positive The program stopped before Phase 3 for unknown commercial reasons (the program passed through several sponsor rotations and no one ultimately carried it through) Why it matters: These are the only published clinical data in humans that we have
And long-term safety studies in humans would address the most significant remaining uncertainty about the compound
Vitamin B12 plays a vital role in many of the bodys functions: Vitamin B12 is important for healthy: Brain function DNA synthesis Energy levels Endurance levels Nerve tissue Red blood cell formation What are signs of vitamin B12 deficiency
