Furthermore, mtDNA depletion can activate the calcineurin/PI3K/AKT signaling axis, upregulate the expression of miR-1245 and Skp2, and suppress the translation of BRCA2 protein
When the desensitized GSH I-encoding gene gshA * was cloned, the activity of the mutant GSH I increased tenfold compared with the wild type enzyme
As a direct antioxidant, GSH quenches reactive oxygen species (ROS), reactive nitrogen species (RNS), and lipid peroxyl radicals, and regenerates oxidised vitamin E and vitamin C back to their active reduced forms placing GSH at the hub of the broader cellular antioxidant network
Presented for research literature review only Kaye MD et al
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