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Unintentional weight loss beyond the expected therapeutic effect, inability to tolerate oral intake, or symptoms preventing normal daily activities all justify clinical reassessment
When skin is exposed to UV radiation from the sun, it triggers cells called melanocytes to produce more melanin pigment for protection
The most successful treatments currently available include glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs), exemplified by semaglutide (approved in 2017, $19.9 billion sales in 2023) 3 and tirzepatide (approved in 2022, $5.3 billion sales in 2023) 4
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