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In parallel, researchers recognized that GLP-1s appetite-suppressing effects could be leveraged to treat obesity
This reaction is essentially a reversal of the thiolase (HADHB or ACAA2) catalyzed reaction of fatty acid -oxidation but is in fact catalyzed by the mitochondrial enzyme acetoacetyl-CoA thiolase (encoded by the ACAT1 gene)
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2022 Sep;150(3):727-735.e6
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