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30 Among the pathways activated by IR and IGF-1R signaling are the RASRAFMEK1/2extracellular signal-regulated kinase (ERK)-1/2 pathway 34 and the phosphatidylinositol-3-kinase (PI3K)AKTmammalian target of rapamycin (mTOR) pathway, two fundamental pathways for tumor cell proliferation and survival (Figure 2)

While the BBB tries to limit systemic inflammation, it can be compromised by cytokines such as tumor necrosis factor (TNF-) and IL-1

Sterility Regardless of route, standard aseptic technique applies: clean the vial stopper and injection site with alcohol, use a new sterile needle for each injection, and allow alcohol to dry before injection

PMID: 33413467