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The 2024 Yang paper in Journal for ImmunoTherapy of Cancer documented NNMT in cancer-associated fibroblasts driving tumour progression (PMID 39067875)

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Chloroform-induced alteration of glutathione S-transferase activity [PMID: 3966926] Laboratory literature summary: Chloroform-induced alteration of glutathione S-transferase activity

Biopharma companies face: Massive competition and potential market saturation with over 500 GLP-1-related clinical trials across 100+ indications Downward price pressure Highly restricted reimbursement and resistance to new indications Mechanism-based stratification can: Enrich clinical trials for responders (response biomarkers) Identify strong responder subgroups (complementary diagnostic) Differentiate competing assets Support development in new indications (biomarker-led indication switching) De-risk late-stage programs (clinical trial design) Past efforts to expand GLP-1s into new indications - such as the semaglutide Alzheimers trial - largely targeted broad patient groups defined by their clinical symptoms or diagnostic labels

If increasing cagrilintide from 0.25 mg to 0.5 mg, hold retatrutide steady