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Proximity-enabled bioreactivity to generate covalent peptide inhibitors of p53Mdm4
Liraglutide, a GLP-1 receptor agonist, inhibits vascular smooth muscle cell proliferation by enhancing AMP-activated protein kinase and cell cycle regulation, and delays atherosclerosis in ApoE deficient mice
Gamma-glutamyl transpeptidase
Future directions include structural modifications to enhance brain targeting (e.g., curcumin nanocrystals, resveratrol phosphate prodrugs), identification of core pharmacophores and direct targets using chemical biology techniques (such as ABPP and CETSA), establishment of standardized evaluation systems for ferroptosis-inhibition potency to enable cross-comparison of EC 50 and therapeutic indices across consistent cell and animal models, and the development of combination strategies integrating natural compounds with synthetic inhibitors (e.g., low-dose Lip-1 with curcumin) to reduce dosage, minimize side effects, and enhance therapeutic efficacy
Nathan DM, Lachin JM, Bebu I et al (2022) Glycemia reduction in type 2 diabetes - microvascular and cardiovascular outcomes
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