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We dissect how these rationally engineered platforms overcome the unique physical and cellular barriers of the osteosarcoma TME, with a critical emphasis on the severe translational hurdles, such as protein corona formation and in vivo stability, that limit clinical progression
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Vesicular and nanocarriers The drug-carrying vesicles in transdermal delivery including liposomes and nanoparticles are one of the most promising methods which ease skin penetration as it improves fluidizing the skin lipids, the drug portioning into the skin, and drug solubilization into the formulations [289, 290]
In fact, despite having a higher objective response rate (ORR) than sorafenibs 9.2%, lenvatinib only achieves an ORR of 24.1% [21]
Methods This study combined human serum proteomics with public single-cell RNA sequencing and spatial transcriptomics data from diabetic kidneys to identify key biomarkers for DKD diagnosis
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