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This indicates that safety signals are more visible in pooled short-term RCTs, while long-term adherence and the risks of weight rebound or metabolic withdrawal post-discontinuation remain difficult to quantify reliably in existing studies

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The larger, longer trial failed to show significant results at all

BV treatment can decrease CD4+, CD4+/Interferon-gamma (IFN-+), and CD4+/IL-17 + T cells while raising CD4+/Foxp3+ T cells in the nervous system and lymphatic systems of rats with acute experimental autoimmune encephalomyelitis (EAE) (Lee MJ

Soon D, Kothare PA, Linnebjerg H, Park S, Yuen E, Mace KF, et al