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Finally, descriptive statistics were used to analyze safety endpoints of the randomized treatments in all participants that were exposed to at least one dose [1]
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Apart from the local adverse effects of these agents, the important limitation is the localization of their effect to the site of application alone
Inadequate tumor coverage may contribute to local recurrence, while even minor overdosing of adjacent organs can lead to long-term complications such as fibrosis, ulceration, fistula formation, or chronic bowel and urinary dysfunction [107]
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