Seiler A, Schneider M, Frster H, Roth S, Wirth EK, Culmsee C, et al
doi:10.1016/j.jbiotec.2015.09.004 Wang D, Wang C, Wu H, Li Z, Ye Q (2016) Glutathione production by recombinant Escherichia coli expressing bifunctional glutathione synthetase

:Basic cofactors consist of: Vitamins A and Vitamin D (11,000 IU and 3000 5000 IU respectively) Vitamin C at 4000+ mg per day Vitamin E B vitamin complex with P5P, biotin and pantethine (without including cyano B12 or folic acid) A 1:1 magnesium:calcium supplement Zinc, 50 mg per day Omega 3 fatty acids, 2-6 caps per day Optional Basic Cofactors include: Glycophospholipids Additional pantethine Multimineral supplements (choline, selenium) Alpha lipoic acid D-Ribose CoQ-10 Titrate B12s while adjusting methylfolate and potassium Methylcobalamin (MeB12) should start at 15-20 mg per day Adenosylcobalamin (AdoB12) should start at 10 mg per week Titrate methylfolate to sufficiency, starting at 1 mg Titrate L-carnitine fumarate (LCF) to effectiveness, starting at 125 mg per day and aiming for 500-1000 mg per day, stopping when an increase of 250 mg makes no difference
For research applications, systemic distribution occurs regardless of administration route, making oral dosing highly effective
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