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The combination of temperature and duration determines whether your medication is still viable, and those two variables interact in ways that are not always intuitive
Langmuir 30 , 78427850 (2014)
In the GR-carmustine system (unsupported) the active site of the protein comprises of the residues Pro160, Ser161, Pro163, Ser177, Gly194, Gly196, Tyr197, Ala199, Ile198, Gly204, Trp287, Ala288, Ile289, Gly290 and Arg291, that play a key role in binding with the drug moiety as observed during docking and refined using QM/MM calculation
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