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Moreover, the beta cell might be vulnerable to both cytokine-mediated destruction [111] and various types of endoplasmic reticulum stress [112]
Emerging technologiesincluding extracellular vesicle (EV) supplementation and microfluidic culture platformsoffer biomimetic environments that may enhance metabolic stability, restore physiological signaling, and improve embryo developmental potential
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In patients with type 2 diabetes, clinical trials have shown that GLP-1s significantly reduce the risk of major adverse cardiovascular events, including nonfatal heart attacks and strokes.[135] For example, semaglutide has been associated with a 20 percent reduction in such events, highlighting its potential to improve cardiovascular outcomes.[136] In June 2025, the American College of Cardiology (ACC) advocated for the early use of GLP-1 therapies as primary treatments for obesity to reduce cardiovascular risk, urging clinicians to consider these drugs as first-line options, highlighting that they outperform lifestyle interventions in efficacy and lower cardiovascular risk with fewer dangers than surgery
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