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Therapeutically applications : Neuromodulators can treat various conditions like chronic migraines, muscle spasticity, TMJ issues, and hyperhidrosis (excessive sweating) by modulating nerve signals to provide relief from symptoms and improve patients' quality of life
Sleep deprivation increases ghrelin production, the hormone that stimulates hunger
50 Activated AMPK then promotes glucose uptake through the translocation of GLUT4, suppresses gluconeogenesis by inhibiting G6Pase and PEPCK, and improves lipid metabolism by inhibiting fatty acid synthesis and promoting its oxidation
doi: 10.1021/acs.jafc.8b05581 32 WangYNMengXCDongYFZhaoXHQianJMWangHYet al
Furthermore, due to enhanced insulin sensitivity, FGF-21 reduces the release of free fatty acids into the circulation, thereby limiting their hepatic uptake
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