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124 As an acetylation-defective mutant, p533KR cannot induce apoptosis, cell cycle arrest, or senescence, but it can regulate the expression of SLC7A11 and induce ferroptosis mediated by reactive oxygen species (ROS)

94 Neutrophil release is facilitated by gradients of mediators across the bone marrow sinus wall, including CXCL1, CXCL2, and G-CSF

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They're not necessarily indicators of intolerance but rather evidence of pharmacological activity