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A noteworthy observation was that several men required concurrent use of antiestrogen therapies such as aromatase inhibitors or tamoxifen to address gynecomastia or elevated estradiol levels
(6) The research team hypothesized that AOD 9604 possibly enhanced the doxorubicin binding to multiple breast cancer cell protein targets, thereby exhibiting greater anti-proliferative activity against the MCF-7 breast cancer cell line compared to chitosan loaded with doxorubicin alone
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