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Wang 1 , David Cassiman 2 , Laurent Gouya 3 , Eliane Sardh 4 , Yanling Hu 5 , Ana Camejo 5 , Tom Brown 5 and Manisha Balwani 6 , (1)University of California San Francisco Medical Center, (2)University Hospital Leuven, (3)Centre Franais Des Porphyries, (4)Porphyria Centre Sweden, Centre for Inherited Metabolic Diseases, Karolinska Institutet, Karolinska University Hospital, (5)Alnylam Pharmaceuticals, (6)Icahn School of Medicine at Mount Sinai Background: Acute hepatic porphyria (AHP) is a group of rare, chronic, multisystem disorders with acute attacks, progressive elements, and long-term complications