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Moreover, NUAK1 inhibition causes tumor ICD through H 2 O 2 /OH accumulation and ER stress, as NRF2, downstream of NUAK1, suppresses antioxidant gene expression [263]
J Orthop Res 21(6):976983
The peptide's circulating half-life is short (minutes to hours), but the transcription factor cascades it triggers persist for days
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