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These CVOT findings are supported by a real-world study performed in over 3 million patients with T2DM from the United States, in which patients treated with SGLT2is did not have a higher risk of any or lower amputation compared with incretins or other glucose-lowering agents [77]
Patients who build strong lifestyle habits during their time on tirzepatide and who have a clear maintenance plan in place before stopping give themselves the best chance of preserving their results
It also allows for rotation between multiple sites, reducing the risk of localized reactions
Hormonal and neural mechanisms of food reward, eating behaviour and obesity
Headache: The Journal of Head and Face Pain, 60(3), 415-423
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