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Contraindications and Use Restrictions GLP-1 medications should not be used by individuals with a personal or family history of medullary thyroid carcinoma, Multiple Endocrine Neoplasia syndrome type 2, known hypersensitivity to semaglutide, or during pregnancy or breastfeeding
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Knudsen and Lau, in a 2019 review of both compounds, describe semaglutide as a redesign of that anchor: lengthening the lipid to a C18 diacid and elaborating the linker increased albumin affinity and slowed clearance further, converting a once-daily molecule into a once-weekly one [5]
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