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BHB is believed to be the predominant energy source for neurons when blood glucose levels are low, such as while fasting for more than 12 h in mice or 24 h in humans [glycogen provides glucose for roughly 24 h in humans] (Chowdhury et al

This suggested that TRX-1 levels are developmentally regulated as the levels decline to that of normal adult levels of 1030 ng/mL by 3640 weeks post-menstrual age