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Marko M, Posekany A, Szabo S et al (2020) Trends of r-tPA (recombinant tissue-type plasminogen activator) treatment and treatment-influencing factors in acute ischemic stroke

It has a high affinity for copper ions (Cu), forming a stable and biologically active complex that enhances coppers bioavailability and intracellular activity

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Remarkably, scrambled-injected Trkb Penk -KO mice developed the expected hyperlocomotor phenotype, whereas Trkb Penk -KO mice injected with Gsto2 -shRNA showed no significant difference in performance compared to control mice at all ages analysed (Fig