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Progestin thickens the mucus in the cervix to prevent sperm from reaching the egg and also thins the lining of the uterus to prevent implantation of a fertilized egg

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The fact that patients in this trial continued to lose weight after gastrointestinal adverse effects had subsided suggests that these effects were not the cause of weight loss

However, upon stopping the medication, they regained approximately two-thirds of the lost weight within a year, resulting in an overall 5.6 percent weight reduction from their starting weight