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That alone is unusual for me

Neurochem Res 37(5):903910 Heneka MT, Kummer MP, Stutz A et al (2013) NLRP3 is activated in Alzheimers disease and contributes to pathology in APP/PS1 mice

This can be a serious side effect

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Store in a cool, dark, and climate-controlled environment, ideally at -20C for long-term storage or 2-8C for current usage, to maintain sequence integrity