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The complexes cause an influx of neutrophils, macrophages, and other B cells and T cells into the tissue Proinflammatory cells secrete damaging reactive oxygen species and more proteins that cause tissue damage

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This oxidative burden is exacerbated by Ang II, which promotes mitochondrial fission via dynamin-related protein 1 (Drp1) and inhibits mitophagy, leading to the accumulation of damaged, ROS-producing mitochondria (Tbara et al., 2025)

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J Inflamm Res