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In healthy adults, GLP-1 regulates blood sugar and appetite, signalling to the brain when the body is full
In the last decade, GLP-1 receptor agonists, also known as GLP-1RAs, have moved from being a promising therapeutic concept to one of the fastest-growing drug classes in metabolic disease
The October 2025 analysis published in the Journal of the Endocrine Society (abstract SUN-659, with full peer-reviewed article at PMC12544991) reported retatrutide at a mean absolute reduction of 16.34 kg and 23.77% body weight versus 11.82 kg and 16.79% for tirzepatide, an indirect advantage in retatrutides favour 20
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