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Following internalization, Fe 3 + is reduced to Fe 2 + by six-transmembrane epithelial antigen of the prostate 3 (STEAP3) and subsequently transported into the cytoplasm by divalent metal transporter 1 (DMT1)

Two downstream consequences are mechanistically central: nicotinamide is preserved for re-entry into the NAD+ salvage pathway (raising intracellular NAD+ availability), and SAM is preserved for other methylation reactions