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One of the most debilitating and defining hallmarks of ME/CFS and Long COVID is post-exertional malaise (PEM), a severe, disproportionate exacerbation of symptoms following even minor physical, cognitive, or emotional exertion
Incretin mimetics have demonstrated safety and efficacy in advanced kidney disease, however multiple studies have shown that use of GLP1-RA have shown improvements in glycemic control, body weight reductions, improved beta cell function, and decreased incidence hypoglycemia as compared to DPP4i in a general diabetes population 26,27,28,29,30,31 , effects which might explain the reduction of acute healthcare utilization observed in this study of patients with CKD treated with GLP1-RA as compared to DPP4i
Many biohackers and patients using 5-Amino-1MQ (often in capsule form) report increased energy, faster workout recovery, and gradual fat loss over a few months
In rodents, but not in humans, GLP-1R is expressed by the C cells of the thyroid gland, and its activation stimulates calcitonin secretion [42, 43]
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