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To the best of our knowledge, this meta-analysis is the first to evaluate the effects and safety of SGLT2i and GLP-1RAs as first-line therapy for T2DM with low cardiovascular risk

2012;17:e919e924

Cardiovascular outcomes and safety of empagliflozin in patients with type 2 diabetes mellitus and peripheral artery disease: a subanalysis of EMPA-REG OUTCOME