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While clinical trials demonstrate significant efficacy, some patients experience suboptimal results or apparent treatment failure
Other risk factors that may increase vulnerability include: Long duration of diabetes (typically more than 10 years) Poor glycaemic control prior to starting GLP-1 therapy (HbA1c significantly above target) Rapid reduction in HbA1c (a drop of more than 2 percentage points [22 mmol/mol] within 36 months) Concurrent hypertension , especially if poorly controlled Diabetic kidney disease (nephropathy), which often correlates with retinopathy severity Previous history of retinal treatment (laser photocoagulation or intravitreal injections) People with type 2 diabetes but no retinopathy appear to have minimal risk of retinopathy progression based on current evidence
It induces vasoconstriction within the cochlea and interferes with potassium ion transport in the stria vascularis, further contributing to auditory dysfunction
Using the drug roflumilast to block PDE4, an enzyme that breaks down cAMP, they were able to shift more neurons toward a longer lasting response
Post-research, the femurs were examined with mid-diaphyseal peripheral quantitative computed tomography (pQCT)
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