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GLP-1s have proven successful for many of these kids, but doctors who oppose their use fear that the drugs tendency to reduce calorie and nutritional intake may affect bone growth, brain development, and even puberty, according to the article

Taken together, these data suggest that GLP-1R agonists need to engage multiple extrahypothalamic and hypothalamic populations simultaneously to exert their inhibitory effects on food intake and body weight, at least in the chronic setting

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