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Paccou J, Compston JE
BMJ 366:l4898
publish landmark study demonstrating Dihexa's synaptogenic properties via HGF/c-Met activation at Washington State University [McCoy et al., 2013]
Glucose regulation is the bigger concern
based on consistent formation of -helical structure in initial rounds of structure calculations in which no hydrogen bond restraints were defined), inter-molecular PRE restraints (4 non-interacting copies of the spin label to account for different spin label orientations), inter- and intra-molecular NOE restraints, and ambiguous distance restraints for residues showing CSPs upon binding
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