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Oxid Med Cell Longev 2015:e426069
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is an inventor on key patents in the field of metabolomics
This macrophage reprogramming is associated with SFN-mediated inhibition of the transcription factor c-Myc, which normally drives M2 polarization, and concurrent activation of the Nrf2 pathway that favors M1-associated gene expression profiles (78)
Yet, this view has shifted with recent findings that uncovered a developmental expression pattern for CHAC2 and a role in stem cell fate determination (Wang et al., 2017)
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