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However, gastrointestinal side effects and loss of lean mass are notable concerns ( Lifestyle interventions, including exercise and dietary modification, remain the cornerstone of obesity and diabetes management, with proven benefits for weight loss, glycemic control, cardiovascular health, and quality of life (30)
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Therefore the nitric oxide required for the modulation of the growth and for the endothelial migration during the vascular growth is maintained in an adequate level 17
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