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, at histone H3 lysine 18 lactylation [H3K18la]), thereby inducing immunosuppressive gene expression (including Arg1 ) and driving macrophage polarization toward the M2 phenotype ( + T cell functionality ( In summary, these findings underscore the pivotal contribution of lactate and Kla to establishing immunosuppressive TME
Johnson JB, John S, Laub DR
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Furthermore, low levels of glutathione can exacerbate oxidative stress and insulin resistance
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