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However, it is encouraging that preclinical and early human studies suggest that GLP-1 agonism appears broadly protective: indeed clinical trials of these agents are being initiated in cardiovascular disease (SELECT and SOUL trials, see below), NASH, and neurodegeneration (Alzheimers and Parkinsons)

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However, prior authorizations and approvals can make ongoing access difficult

Zepbound is an even newer breakthrough, acting as a dual agonist by mimicking both GLP-1 and another hormone called GIP (Glucose-dependent Insulinotropic Polypeptide)

Addgene plasmid # 87067) onto the C-terminus end of the SNAP-GLP-1R vector (Cisbio), followed by site-directed mutagenesis of the GLP-1R stop codon