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An animal model with relevance to schizophrenia: sex-dependent cognitive deficits in osteogenic disorder-Shionogi rats induced by glutathione synthesis and dopamine uptake inhibition during development

Starting with a lower dose helps your body adjust gradually, and most patients see improvements over time

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To date, no selective PDE1B or PDE10A inhibitors have been approved for clinical use, whereas existing PDE inhibitors have been associated with adverse events linked to their isoform profiles