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Downregulation of LAT1 ( SLC7A5 ) suppresses methionine input, thus reducing the level of cellular SAM, resulting in methylation depletion of some histones and inhibition of tumor growth
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a , Structureactivity relationship of the tricyclic system
Inhibiting estrogen-induced hTERT and AKT phosphorylation, and also estrogen-induced nuclear translocation of hTERT by LY294002 illustrates that phosphorylation of hTERT is an important pathway for both estrogen-induced hTERT nuclear translocation and telomerase activity [100]
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