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MOTS-c modulates the FOXO transcription factors and regulates cellular senescence, the state in which aged or damaged cells stop dividing but refuse to die, instead secreting a cocktail of inflammatory signals known as the senescence-associated secretory phenotype (SASP)

That is the reason why it is safe to use that within that period and not beyond that

Theoretical risks Long-term or high-frequency use raises theoretical concerns about copper accumulation

Presented for research literature review only Morrison RJ et al

Cagrilintide showed similar directional improvements, though the magnitude was generally proportional to the degree of weight loss rather than suggesting independent cardiovascular effects