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They do not share the same evidence base
Feb-Mar 2003;523-524:209-216
Semaglutide primarily works by regulating appetite and supporting weight loss through GLP-1 receptor activation and does not directly affect testosterone levels
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Expert Review of Endocrinology & Metabolism, 2025) The Fertility Paradox Worth Discussing With Your Provider For patients not actively trying to conceive, restored ovulation can be an unexpected and clinically significant side effect of treatment meaning contraception planning should be part of the conversation when starting GLP-1 therapy for PCOS, not an afterthought
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