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FDA-approved GLP-1 drugs are injections or oral medications that are designed to mimic the effects of GLP-1, a naturally occurring hormone that regulates blood sugar and appetite in the body
Thus in addition to increasing GLP-1 concentration, recent research shows that it also lowers insulin concentration and stabilizes ghrelin levels
"Any kind of bloating, pressure, change in urine, bowel symptoms or early satiety that's present for two weeks should be evaluated," said Villella
GLP-1 medications work by mimicking natural gut hormones involved in appetite regulation, blood sugar balance, and satiety
FIDELIO-DKD was a phase 3 trial of finerenone, in addition to standard of care, in participants with T2DM, moderately advanced CKD (mean baseline eGFR was 44 mL/min/1.73 m 2 with a median UACR of 852 mg/g) with the majority (87%) having macroalbuminuria [100]
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