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After deliberations, the committee recommended the approval of tirzepatide for chronic weight management subject to the condition that firm should conduct Phase 4 clinical trial (post-marketing surveillance), Reuters reports
Are GLP-1 drugs a long-term solution
Improper technique can alter concentration and lead to inaccurate dosing
This equates to around 7.6 million fewer people being counted as obese compared to three years ago, meaning a potential future reduction in obesity-related health conditions, including cancer, heart disease, stroke, and mental health issues
Structural and molecular differences include: Amino acid composition : Semaglutide contains specific substitutions that confer DPP-4 resistance, whereas native GLP-1 is rapidly cleaved by this ubiquitous enzyme Albumin binding : The fatty acid side chain attached to lysine at position 26 in semaglutide enables prolonged circulation through albumin binding, a property absent in natural GLP-1 Molecular stability : Structural modifications protect semaglutide from enzymatic degradation and renal clearance that rapidly eliminate native GLP-1 From a clinical perspective, natural GLP-1 cannot be administered as a therapeutic agent due to its extremely short half-life, which would require continuous intravenous infusion for sustained effect
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