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Accumulated unfolded proteins bind to immunoglobulin-binding proteins, activating PERK, IRE-1, as well as transcription factor-6 and phosphorylating eIF2a
In our study, as the intracellular -GC level was only increased slightly compared with that of original strain W303-1b when F pathway was introduced, we artificially introduced a flexible six-glycine linker between the two enzymes of G pathway as well as P pathway to improve the coupling efficiency by mimicking the native domain fusion of GshF
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Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function
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