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Its safety profile across roughly 900 participants remains one of the strongest in this peptide category
There are however cases (including IGF-1R [107, 109], ErbB-1 [110], ErbB-2 [111], Ron [112], FGFR1 and FGFR2 [113], VEGFR1 and R2 [114, 115]) in which the intact receptors translocate to the nucleus
In support of this observation, BSA, which exhibited no binding to Syn WT bound to Syn S129E , suggesting a partial exposure of its hydrophobic core 35
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