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4 How Vitamin D Helps Regulate This Immune Overreaction Vitamin D supplementation (800-1000 IU) has been shown to have anti-inflammatory properties in addition to its role in calcium metabolism

19 Across the included studies, sample sizes ranged from 8 to 193 participants, and participants ages ranged from 18 to 93 years

Nature 478 , 395398 (2011)

It upregulates the expression of vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), and their respective receptors at sites of injury, directly promoting angiogenesis and epithelial repair

A randomized controlled trial by Miller, Wagner, and colleagues published in the Archives of Facial Plastic Surgery in 2006 evaluated topical copper tripeptide complex on CO2 laser-resurfaced skin in 13 patients and found no statistically significant differences between groups for resolution of erythema, wrinkles, or overall skin quality on objective assessment, although subjective patient-reported skin quality favored the GHK-Cu side (p = 0.04)