A typical rodent dose-response protocol might test 100mcg/kg, 200mcg/kg, and 400mcg/kg groups against vehicle controls, with GH serum sampling at 15, 30, and 60 minutes post-injection to capture peak secretion
Does not meaningfully raise IGF1 and shows a placebolike safety profile in human studies
That said, the women in the placebo groups also showed meaningful improvement, suggesting that there was a noticeable placebo effect that boosted desire as well
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Future research could help answer questions about how common it is for gabapentin to reduce the benefits of semaglutide and what factors might make someone more likely to experience these effects