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GLP-1 is rapidly broken down and inactivated by the enzyme dipeptidyl peptidase-4 (DPP4), which is distributed throughout the body, both on the surface of cell membranes, and free in the bloodstream
The emergence of new clinical evidence appears to have far less of an impact on GPs a finding supported by verbatim analysis
Le smaglutide possde des substitutions et des modifications qui le rendent plus rsistant au clivage protolytique et qui ralentissent son limination par lorganisme, ce qui permet une administration hebdomadaire (en comparaison, la formulation originale de lexnatide ncessitait deux injections quotidiennes) 3
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