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GLP-1Rs are expressed in the pancreas, intestinal intraepithelial lymphocytes, myocardium, adipose tissue, kidney, liver, blood vessels, lungs and in the CNS.2,3 Although GLP-1 is known for its incretin effect, which it shares with glucose-dependent insulinotropic peptide (GIP), the intake-regulating action, essential for its efficacy against obesity, occurs through its interaction with receptors located in the CNS.1,5 The GLP-1 peptide can reach the central nervous system (CNS) via peripheral vagal afferents, which transmit its action through the nodose ganglion to the nucleus tactus solitarius (NTS)
Kowalczyk, A., Tuberoso, C
In contrast, Ozempic is specifically approved for the treatment of type 2 diabetes
Other frequent side effects include: Headache and dizziness Fatigue and decreased energy Injection site reactions Dyspepsia and gastro-oesophageal reflux More serious but less common adverse effects include pancreatitis, gallbladder disease, and hypoglycaemia (particularly in patients taking concomitant diabetes medications)
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